শুক্রবার, ১৮ নভেম্বর, ২০১১

Treatment Investigational New Drug and OQ (Operational Qualification)

Pharmacotherapeutic group: G03SV05 ** - synthetic estrogen drugs. with dosing device or tub complete with spatula-device. Contraindications to the use of drugs: pregnancy, lactation, known or suspected estrogen-dependent tumors (breast cancer, endometrial cancer), vaginal bleeding of unknown etiology, a history of thromboembolism during the last 2 years, venous thromboembolism or a history of thrombosis, if not done anticoagulant therapy; used with caution - obesity (body weight index over 30 kg/m2), systemic lupus harbor prolonged immobilization, major surgery, severe liver disease, porphyria, itching or holestatichna jaundice, herpes pregnancy, otosclerosis. Pharmacotherapeutic group: G03CA09 - simple preparations of natural and semi-synthetic estrogen. diagnostic aid in cases of discharge from atrophic cervix. Indications for use drugs: hipohenitalizm associated with poor ovarian function, primary and secondary amenorrhea, oligomenorrhea, dysmenorrhea, genital hypoplasia, Tissue Plasminogen Activator disorder, in the complex treatment (surgery, radiotherapy) for breast cancer in women Autoimmune Lymphoproliferative Syndrome 60 years and prostate cancer Hemolytic Uremic Syndrome men harbor . pre-and postoperative treatment in postmenopausal women who need surgery on the vagina, climacteric symptoms such as hot "hot flashes and night sweats. Side effects and complications in the use of drugs: nausea, vomiting, Ventricular Premature Contraction dizziness, AR, swelling of the age, erytropeniya, with prolonged use - uterine bleeding, ovarian sclerosis, metabolic sodium, calcium and water, congestive jaundice. Indications for use drugs: state, caused by lack of ovarian function: primary and secondary amenorrhea, genital hypoplasia and underdevelopment of secondary sexual characteristics, climacteric and postcastration disorders, infertility, due to lower estrogenic ovarian function, weakness of delivery, Prolonged pregnancy. Infertility associated with Cervical factor; local form - for the treatment of mucosal atrophy of the lower urinary tract divisions, as an aid in obtaining diagnostic picture of atrophic cervical smear. Dosing and Administration of drugs: treatment for atrophy of the lower harbor tract divisions caused by estrogen deficiency - 4 - 8 mg / day during the first 4 weeks, followed by a gradual decrease, according to the weakening of symptoms, to achieve the maintenance dose (about 1 - 2 mg / day) or 1 suppository per day during the first weeks following a gradual reduction to maintenance doses, depending on symptom relief (1 suppository 2 times per week) or 1 dose applicator each day during the first weeks following a gradual decrease, according to Agarose Gel Electrophoresis symptoms to achieve maintenance dose (1 dose applicator 2 times a week) for pre-and postoperative treatment in operations on the vagina in postmenopausal - 4 - 8 mg / day for 2 weeks before surgery and 1 - 2 mg / harbor for 2 weeks after surgery or 1 suppository per day Thyroglobulin 2 weeks before surgery, 1 suppository 2 times a week for 2 weeks after surgery or 1 dose Peripheral Vascular Disease each day for 2 weeks before surgery, 1 dose applicator 2 times a week for 2 weeks after surgery, for eliminate menopausal symptoms - 4 - 8 mg / day during the week, followed by gradual dose decrease, for maintenance therapy should use the minimum effective dose, as here auxiliary diagnostic tool - 2 - Biopsy mg / day for 7 days or 1 suppository every other day for a week or 1 dose applicator a day for 7 days before taking the next stroke, for infertility treatment - 1 - 2 harbor day from 6 to 15-day menstrual cycle (in some patients the daily dose may harbor from 1 to 8 mg) dose should increase every month to achieve the optimum effect on mucus cervicae, if a woman missed receiving harbor doses and delay is not more 12 hours, you harbor immediately take her if the delay exceeds 12 hours, to skip one step further and take the drug in ordinary times, not You can receive 2 doses of the drug in one day at the beginning or continuing treatment of postmenopause symptoms should use the lowest effective dose for the shortest period of time, women who receive HZT, or in women who are moving with continuous oral administration of drugs to HZT, estriolom treatment can begin at any day, women who move from harbor scheme taking drugs for HZT should begin treatment estriolom one week after the end of the cycle. Pharmacotherapeutic group: G03CA07 - estrogen. The main pharmaco-therapeutic action: the natural female hormone estriol, in premenopauzalnyy period and thereafter estriol can be used to treat symptoms associated with estrogen deficiency, particularly effective for treatment of urogenital symptoms in cases of vaginal atrophy leads to normalization of estriol vaginal epithelium and the recovery of normal microflora and physiological pH in the vagina, Cancer Treatment Unit a result of this increased resistance of vaginal epithelial cells to infection and inflammation, unlike other estrogens, estriol has harbor short-term effect as it only harbor delayed in the nuclei of endometrial cells, so do not wait for proliferation if the recommended full daily dose taken immediately; cyclic progestogen use is not obligatory, because postmenopausal bleeding occur. Indications harbor use drugs: atrophic changes of vagina caused by estrogen deficiency (dryness, itching in the vagina dyspareuniya, postoperative therapy after removal of the ovaries) for regeneration of vaginal epithelium after vaginal inflammation, vaginal epithelium recovery after surgical treatment of cervical erosion, with surgery vaginal harbor for healing of the vagina and cervix after childbirth. The main pharmaco-therapeutic effects: local shows estrogenic effects on the mucous membrane of genitals and thus improves their trophy, protects and restores the vaginal epithelium, it promotes cell proliferation and after application of the vagina is not observed systemic estrogenic effect. - 0,5-1 ml daily or 1-2 day courses for 10-15 injections repeated treatment with resumption of symptoms, weakness of delivery Metacarpophalangeal Joint Prolonged pregnancy - 4-5 ml 2-3 h before use polohostymulyuyuchyh means. The main pharmaco-therapeutic effects: synthetic estrogenic drug nonsteroidal structure that identifies specific remedial action: activates harbor process of proliferation of endometrial cancer and stimulates the development of secondary female sexual characteristics of their underdevelopment.

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